space of Disse

Hepatocytes are separated from the sinusoids by the space of Disse.

His name is associated with the "space of Disse", which is a perisinosoidal space of the liver.

It receives lymph from the space of Disse and drains it into the surrounding lymphatic vessels.

Such a change, in combination with the capillarisation of the space of Disse, might reduce macromolecular exchange between the sinusoids and the hepatocytes.

The endothelial cells have no basement membrane and are separated from the hepatocytes by the space of Disse, which drains lymph into the portal tract lymphatics.

The Space of Disse also contains Ito cells, also called hepatic stellate cells, which store fat or fat soluble vitamins (like vitamin A).

The fibrosis in cirrhosis can lead to destruction of other normal tissues in the liver: including the sinusoids, the space of Disse, and other vascular structures, which leads to altered resistance to blood flow in the liver and portal hypertension.