The gustatory nucleus is a component of the solitary nucleus.

Cough receptors project to relay neurones in the solitary nucleus, which project to other parts of the respiratory networks.

It relays information from the taste area of the solitary nucleus to the ventral posteromedial nucleus of the thalamus.

The intermediate nerve reaches the posterior cranial fossa via the internal acoustic meatus before synapsing in the solitary nucleus.

Action potentials triggered in the baroreceptor ending are then conducted to the brainstem where central terminations (synapses) transmit this information to neurons within the solitary nucleus.

These action potentials are conducted to the solitary nucleus in the central nervous system by axons and have a reflex effect on the cardiovascular system through autonomic neurons.

They are innervated by the seventh cranial nerve, more specifically via the submandibular ganglion, chorda tympani, and geniculate ganglion ascending to the solitary nucleus in the brainstem.

The solitary nucleus, which contains the general visceral afferent fibers (GVA) for taste, as well as the special visceral afferent (SVA) column.

It receives signals from the caudal, cardio-respiratory part of the solitary nucleus and sends signals to the lower medulla oblongata, the spinal cord, the amygdala and the lateral hypothalamus.

In addition, the facial nerve receives taste sensations from the anterior two-thirds of the tongue via the chorda tympani; taste sensation is sent to the gustatory portion of the solitary nucleus.

Axons from the rostral (gustatory) part of the solitary nucleus project to the ventral posterior complex of the thalamus, where they terminate in the medial half of the ventral posterior medial nucleus.

The receptors within the brain are not completely understood, although they are thought to be contained in the hypothalamus and also in the solitary nucleus, where nesfatin-1 is believed to be produced via peroxisome proliferator-activated receptors (PPARs).

In the human brain, the solitary nucleus (nucleus of the solitary tract, nucleus tractus solitarii, NTS) is a series of nuclei (clusters of nerve cell bodies) forming a vertical column of grey matter embedded in the medulla oblongata.

In the cerebellum, the PICA supplies blood to the posterior inferior portion of the cerebellum, the inferior cerebellar peduncle, the nucleus ambiguus, the vagus motor nucleus, the spinal trigeminal nucleus, the solitary nucleus, and the vestibulocochlear nuclei.