The most common site of distant metastasis is the lung.

The final group includes patients with distant metastases (M1) that were found at the time of diagnosis.

Distant metastases are also common, even if the primary tumor is controlled.

Approximately 50% of patients with recurrent disease experience distant metastasis.

About 30% of tumors are malignant and have local or distant metastases.

Prognosis is related to tumor size and the presence of distant metastases.

After surgery, many patients develop regional or distant metastases.

The prognosis for patients with distant metastases is poor.

Radiation therapy may be used to palliate central disease or distant metastases.

Patients with distant metastases have a poor prognosis and can be appropriately offered treatment on a clinical trial.