Anaesthetic agents causing myocardial depression, such as cyclopropane and trichlorethylene, are best avoided.

Cardiovascular effects are primarily those of direct myocardial depression and bradycardia, which may lead to cardiovascular collapse.

Hypotension requires treatment with intravenous fluids; vasopressors may be required to treat myocardial depression.

TNF and other cytokines can cause myocardial depression.

PWP (may cause increase due to myocardial depression)

When the solution is injected in the left atrium, myocardial depression is more pronounced suggesting that the coronary bed is the site of action.

It is an alpha-1 selective adrenoceptor antagonist with direct myocardial depression action; therefore, it results in no reflex tachycardia.

Ward round by [Dr C] queried myocardial depression as a cause of the pulmonary oedema.

Cardiovascular system reactions: Cardiovascular reactions are depressant and may be characterised by hypotension, myocardial depression, bradycardia, and possibly, cardiac arrest.

He also found out that the use of cardiac stimulant might alleviate myocardial depression in the presence of shock (first treatment on humans with shock was in 1950).

Calcium channel blockers of the diltiazem/verapamil type: Intravenous treatment with dantrolene and concomitant calcium channel blocker treatment may lead to severe cardiovascular collapse, abnormal heart rhythms, myocardial depressions, and high blood potassium.

Chloroform (which was first used in 1847) used on its own produces myocardial depression, however the excitatory properties of the alcohol and ether contained with the choloroform in the A.C.E. mixture was believed to reduce this.