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This mutation allows for unregulated calcium deposition within muscular arteries.
They give rise to medium-sized vessels known as distributing arteries (or muscular arteries).
In muscular arteries wall thickening may imply instead (or also) a thickening of the medial wall.
Whether or not wall thickening in the carotid artery and the femoral artery (or other muscular arteries) have the same meaning is as yet uncertain.
Vascular disease is a pathological state of large and medium sized muscular arteries and is triggered by endothelial cell dysfunction.
The sural arteries (inferior muscular arteries) are two large branches, which are distributed to the gastrocnemius, soleus, and plantaris muscles.
Distributing arteries (or muscular arteries) are medium-sized arteries that draw blood from an elastic artery and branch into "resistance vessels" including small arteries and arterioles.
It is readily visualized with light microscropy in sections of muscular arteries, where it is thick and prominent, and arterioles, where it is slightly less prominent and often incomplete.
Postductal coarctation is most likely the result of the extension of a muscular artery (ductus arteriosus) into an elastic artery (aorta) during fetal life, where the contraction and fibrosis of the ductus arteriosus upon birth subsequently narrows the aortic lumen.