metachronously

With multiorgan involvement, the sites involved can be affected at the same time (synchronously) or at different unrelated periods (metachronously).

Despite adequate resection and being histologically normal, the remaining locoregional tissue has an increased risk for developing multiple independent cancers, either synchronously or metachronously.

Men with IgG4-related prostatitis may present synchronously or metachronously with manifestations of IgG4-RD at other sites anywhere in the body.