The drug flow has become a major irritant in relations between the two countries.

Back then, as now, the major municipal irritant was taxes.

The issue of United States bases has been a major irritant in relations between the two countries.

Either way, she is a major irritant.

The issue has been a major irritant in American-Turkish relations.

During the investigation, the issue became a major irritant in relations between the United States and Italy.

The shift in power has been a major irritant.

But others said that being constantly asked about the move by reporters, family and friends during the week of such a huge game was a major irritant.

The Optherian's obsequious behavior could quickly become a major irritant.

The proclamation was a major irritant that contributed to the American Revolution.