But it can be difficult to know when to institute treatment, which can have serious side effects.

Institute treatment protocol as per Clinical Practice Guideline

"You have to be very careful about instituting treatment for something when you know from first principles that the treatment is not likely to be efficacious."

We recommend that the WHO clinical indicators of hypoxaemia (which we have validated) be used to institute treatment with oxygen in referral hospitals where oxygen is available.

Trimble EL, Adams JD, Vena D, et al.: Paclitaxel for platinum-refractory ovarian cancer: results from the first 1,000 patients registered to National Cancer Institute Treatment Referral Center 9103.

In certain circumstances in which the males are young, no comorbidities are recognized, and laboratory tests are normal, one should look for the underlying cause of their erectile dysfunction before instituting treatment since the disease process may be more serious than the ED itself.