These changes cause neurons to become hyperexcitable and can lead to spontaneous seizures.

CA1 is hyperexcitable when the CA3 region is damaged.

Dr. Walters believes that for a nerve cell to become hyperexcitable when it or its neighbor has been injured makes evolutionary sense.

The hyperexcitable corticomotoneurons drive anterior horn cells into metabolic deficit, resulting in cell degeneration and death.

Neurons that are in a hyperexcitable state due to trauma may create an epileptic focus in the brain that leads to seizures.

As this channel is important for action potential generation in neurons, it is expected that the Q1489K mutant results in hyperexcitable neurons.

During impulse conduction some aberrant current that escaped a demyelinated axon can circulate in the exterior and depolarize an adjacent demyelinated, hyperexcitable axon.

"These babies need a lot of help from caretakers to maintain control of their hyperexcitable nervous systems," Dr. Griffith said, adding that it is also important not to let the baby cry.

It is this process in which hyperexcitable neural networks form that is referred to as epileptogenesis, and it is during this latent period that symptoms of epilepsy first occur.

Neuronal circuits that are epileptic are known for being hyperexcitable and for lacking the normal balance of glutamatergic neurons (those that usually increase excitation) and GABAergic ones (those that decrease it).