Those with severe hemophilia, about half the hemophilic population, may use the factor three times a week or more.

An example is in about 10% of carrier mothers of hemophilic boys.

For many years, researchers sought to produce cheaper and more readily available blood concentrates to stop hemophilic bleeding.

He was not conscious of any marked change from a "hemophilic liberal," as he once called himself, to - whatever it was he became.

Heterosexual HIV-1 transmission and viral load in hemophilic patients.

He began as "a near-hopeless hemophilic liberal," he writes in his autobiography, "Where's the Rest of Me?"

He was the first physician to identify the relationship between hemophilia and hemophilic arthropathy, as well as the first surgeon to perform a successful internal fixation of proximal femur fractures.

To the Editor: As an HIV-positive hemophilic heterosexual male infected through contaminated blood-clotting products, I have been faced many times over the last few years with the question of how and when to inform a woman of my status.

EpCAM (epithelial cell adhesion molecule, ESA, TROP1) is hemophilic CA-independent cell adhesion molecule expressed on the basolateral surface of most epithelial cells.

Khalid Ali Jabr, 51, a clerk in a Baghdad government office, watched five of his seven hemophilic sons die from AIDS after injecting tainted blood products that Mr. Jabr said came from Mérieux.

In the past he had been, by his own admission, 'a near-hopeless hemophilic liberal' and a devout follower of Franklin Roosevelt, but by the late forties he was rabidly anti-communist, an FBI informer and a Republican in all but name.

There may also be something fitting about a man renowned for his contradictions (a "hemophilic liberal" who became a conservative poster boy, a big-government hater who created a huge national debt) getting a biographer who argues that Mr. Reagan was "a great President" and "an apparent airhead" endowed with an "encyclopedic ignorance."

In hemophilia it may occur spontaneously, and recurrent hemarthroses are a major cause of disability in that patient group due to hemophilic arthropathy, requiring synovectomy, joint replacement and increased medical therapy to prevent further bleeding episodes, although it is controversial whether clotting factor administration adequately prevents hemarthroses.

At the end of the survey the number of registered haemophilic patients was 1818, and 1584 were tested for HIV antibodies.

Concentrates of clotting factors VIII and IX transmitted HIV to many haemophilic patients during the early 1980s.

Joint damage from haemarthrosis (haemophilic arthropathy), potentially with severe pain, disfigurement, and even destruction of the joint and development of debilitating arthritis.

The number of haemophilic patients dying due to infection with HIV for each year from 1980 to 1991 was 1, 0, 0, 1, 0, 1, 4, 8, 14, 20, 24, and 35.

Dr Christine Lee (Mrs Pounder) has been awarded M.D. (London) July 1989 in recognition for her work on Hepatitis in haemophilic patients.

This study was carried out to determine the number of haemophilic patients seropositive for HIV antibodies and the mortality from HIV infection and to confirm that young children were not being exposed to the virus.