glomerular basement membrane

This will cause thinning and splitting of the glomerular basement membrane.

All three of these alpha chains are present in the glomerular basement membrane of normal individuals.

Increased 3DG is correlated to increased glomerular basement membrane width.

Glomerular basement membrane, a part of the glomerulus which helps separate urine from blood

The glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood.

Visceral layer - Lies just above the thickened glomerular basement membrane and is made of podocytes.

The immune complexes are formed by binding of antibodies to antigens in the glomerular basement membrane.

Angiotensin I converting enzyme inhibitors may act in reducing glomerular basement membrane pore size.

Decreased perlecan in the glomerular basement membrane has a central role in the development of diabetic albuminuria.

The glomerular endothelium sits on a very thick (250-350 nm) glomerular basement membrane.

Podocytes line the other side of the glomerular basement membrane and form part of the lining of Bowman's space.

Glomerular basement membrane

On electron microscopy, subepithelial deposits that nestle against the glomerular basement membrane seems to be the cause of the thickening.

The defect is in the Laminin beta 2 gene on chromosome 3p21 which encodes a protein essential to the glomerular basement membrane.

This finding is due to immune complex deposition along the glomerular basement membrane, leading to a typical granular appearance in immunofluorescence testing.

The glomerular basement membrane is also negatively charged in the body; some studies suggest that this prevents the filtration of albumin in the urine.

It reveals thinning of the glomerular basement membrane from the normal 300 to 400 nanometers (nm) to 150 to 250 nm.

Mesangial cells also have phagocytic activity, removing proteins and other molecules trapped in the glomerular basement membrane or filtration barrier.

Microscopically, MGN is characterized by a thickened glomerular basement membrane without a hypercellular glomerulus.

Nephrotic syndrome is a change in the structure of the glomerular filtration mechanism usually in the glomerular basement membrane.

It is a major proteoglycan component in the glomerular basement membrane and may play a role in the renal filtration and cell-matrix interactions.

The disease is caused by a defect in the structure of the type-IV collagen fibrils of the glomerular basement membrane.

Renal failure is ultimately due to damage caused to the Glomerular Basement Membrane by immune system cells attacking in response to these antibodies.

The glomerular basement membrane (GBM) of the kidney is the basal lamina layer of the glomerulus.

Immune complexes (antigen-antibody complexes formed during an infection) become lodged in the glomerular basement membrane below the podocyte foot processes.