Mousepox causes skin lesions and generalized disease, which can be fatal.

BoHV-1 also causes a generalized disease in newborn calves, characterized by enteritis and death.

Symptoms in newborns take either of two presentations: generalized disease or predominantly neurologic disease.

It progresses to a more generalized disease affecting the lymph nodes, bone marrow and spleen.

These 'biological false-positive' reactions have many causes, including many virus diseases, vaccinations, and some other generalized diseases.

NSAIDs for tender lymphnodes and fever, corticosteroids are useful in severe extranodal or generalized disease.

Symptoms of congenital Type III Galactosemia are apparent from birth, but vary in severity depending on whether the peripheral or generalized disease form is present.

The man's skeleton showed signs of significant calcium deficiency, and his spine also suffered the early stages of spondylosis deformans, a generalized disease of aging that is secondary to the degeneration of intervertebral disks.

The stage of the disease at presentation is a strong determinant of survival, but it has little influence on the choice of therapy since almost all patients, except for rare patients with solitary bone tumors or extramedullary plasmacytomas, have generalized disease.

Lepromatous leprosy is at the other end of the spectrum, with a much more generalized disease, diffuse involvement of the skin, thickening of many peripheral nerves, and at times involvement of other organs, such as eyes, nose, testicles, and bone.