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'Severe haemorrhage will also result in an increased filtration fraction.'
The filtration fraction is the amount of plasma which is actually filtered through the kidney.
This would be reflected by a high filtration fraction, showing that the kidneys have to do more work with the fluid they are receiving.
Diuretics such as loops and thiazides decrease the filtration fraction.
Because the filtration fraction has increased, there is less plasma fluid in the downstream peritubular capillaries.
Compare to filtration fraction.
The filtration fraction, therefore, represents the proportion of the fluid reaching the kidneys which passes into the renal tubules.
No significant alteration of glomerular filtration rate, effective renal plasma flow, total renal resistances, or filtration fraction was observed between or within the groups.
Catecholamines (Norepinephrine and Epinephrine) increase the filtration fraction by vasoconstriction of afferent and efferent arterioles, which is possibly activated by alpha 1 adrenergic receptors.
Proteins present in the gel filtration fractions in the high molecular weight range (fractions 13-17) were separated by SDS-PAGE followed by silver stain.
In renal physiology, the filtration fraction is the ratio of the glomerular filtration rate (GFR) to the renal plasma flow (RPF).
Our observations that the drop in urinary albumin excretion correlated with the changes in filtration fraction but not with the drop in blood pressure are consistent with the second possibility.
The predominant role of intraglomerular capillary pressure reduction is supported by the correlation between changes in urinary albumin excretion and in filtration fraction, but filtration fraction did not vary, a finding consistent with previous reports.
The filtration fraction was calculated by dividing glomerular filtration rate by effective renal plasma flow, and total renal resistances by dividing the mean arterial pressure (obtained by an automatic device during tracer infusion) by effective plasma flow.
The device's design requirements would require the filtration fraction in the glomerulus to vary between 15%-20%, or the filtration reabsorption in the proximal convoluted tubule to vary between 65%-70%, and finally the urea concentration in urine (collected at one of the two outlets of the device) to vary between 200-400mM.