Crosby-1962 questioned whether, in the human, it exists independently of the accessory facial nucleus.

The facial nucleus itself can be affected by infarcts of the pontine arteries.

The hypothesis states that, after trauma, axons project from the facial nucleus to incorrect peripheral muscle groups.

Damage to the central nervous system motor pathway from the cerebral cortex to the facial nuclei is found in the pons.

Neurons that form the facial nucleus are produced in r4, but move along the anteroposterior axis of the hindbrain into r6, after which they move dorsolaterally.

Also, it projects to the facial nucleus, hypoglossal nucleus and parabrachial area along with parts of the caudal parvocellular reticular formation.

The (VRG) is a column of neurons located in the ventrolateral region of the medulla, extending from the caudal facial nucleus to -400μm obex.

Through the combination of anterograde and retrograde tracing techniques in monkeys it was found that the facial nucleus, which supplies muscles of the lower face are innervated bilaterally.

The contraction amplitude after using a CFNG is usually not very powerful, but it results in a relatively spontaneous smile because the contralateral healthy facial nucleus controls the movements.

The corticobulbar tract innervates cranial motor nuclei bilaterally with the exception of the lower facial nuclei which are innervated only unilaterally (below the eyes) and cranial nerve XII which is innervated unilaterally as well.

In the adult rat central nervous system (CNS), plexin A4 was present in neurons and fibers throughout the brain and spinal cord, including neocortex, hippocampus, lateral hypothalamus, red nucleus, facial nucleus, and the mesencephalic trigeminal nucleus.

Woody et al. demonstrated that eyeblink conditioning (EBC), a form of classical conditioning for studying neural structures and mechanisms underlying learning and memory, in a cat is associated with increased excitability and input in the neurons in sensorimotor cortical areas and in the facial nucleus.

The expression of CCL2 in neurons is mainly found in the cerebral cortex, globus pallidus, hippocampus, paraventricular and supraoptic hypothalamic nuclei, lateral hypothalamus, substantia nigra, facial nuclei, motor and spinal trigeminal nuclei, gigantocellular reticular nucleus and in Purkinje cells in the cerebellum.

Parasympathetic efferent fibers of the facial nerve (preganglionic fibers) arise according to some authors from the small cells of the facial nucleus, or according to others from a special nucleus of cells scattered in the reticular formation, dorso-medial to the facial nucleus.