It senses the voltage change caused by the end-plate potential from nervous stimulation and propagated by sodium channels as action potentials to the T-tubules.

The small depolarization associated with the release of acetylcholine from one synaptic vesicle is called a miniature end-plate potential (MEPP).

It soon became generalized that the end-plate potential (EPP) alone is what triggers the muscle action potential, which was manifested through contractions of the frog legs.

At this stage, end-plate potentials (EPPs) can still be detected, but are too small to reach the threshold potential needed for activation of muscle fiber contraction.

Nm is located in the neuromuscular junction which causes the contraction of skeletal muscles by way of end-plate potential (EPPs).

The T-tubule system contains voltage-dependent calcium channels known as dihydropyridine receptors (DHP) which are activated by the end-plate potential.

Action potentials from the central nervous system cause end-plate potentials at the NMJ which causes sodium ions to enter and depolarise the muscle cells.

Bernard Katz pioneered the study of these mEPSPs at the neuromuscular junction (often called miniature end-plate potentials) in 1951, revealing the quantal nature of synaptic transmission.

In the neuromuscular junction of vertebrates, EPP (end-plate potentials) are mediated by the neurotransmitter acetylcholine, which is also the main transmitter in the central nervous system of invertebrates.

The diffusion of Na and K across the receptor causes depolarization, the end-plate potential, that opens voltage-gated sodium channels, which allows for firing of the action potential and potentially muscular contraction.

Because of the differences in electrochemical gradients across the plasma membrane, more sodium moves in than potassium out, producing a local depolarization of the motor end plate known as an end-plate potential (EPP).

This was shortly after transmitter release at the frog neuromuscular junction was found to induce postsynaptic miniature end-plate potentials that were ascribed to the release of discrete packages of neurotransmitter (quanta) from the presynaptic nerve terminal.