In lung cancer there is evidence for the down-regulation of miR-1.

This down-regulation is believed to be in response to oxygen levels.

The influence of this motif on down-regulation was not investigated, however.

They noticed that long-term exposure led to a down-regulation of binding sites.

Down-regulation is a process resulting in decreased gene and protein expression.

In addition, down-regulation of per1 can enhance tumor growth in mammals.

It's likely that the down-regulation of testosterone production seen here is an evolutionary adaptation to increase reproductive success.

However, there are many illnesses caused by down-regulation of eIF2 through its upstream kinases.

With long-term use of moclobemide, there is a significant down-regulation of B-adrenoceptors.

Similar treatments regarding the down-regulation of netrin-1 are also being looked into for metastatic breast and colorectal cancers.

The alpha-2 adrenergic receptors also undergo agonist-induced desensitization and down-regulation.

However, expression analysis of these genes did not provide evidence of down-regulation in CC cell lines.

The pattern of gene expression (up- or down-regulation) was similar for the genes when the two methods of measurement were compared.

The problem can be solved by genetic engineering to interrupt down-regulation of nitrogenase in response to nitrogen excess.

Thus a phosphorylation pathway may not be involved in agonist-induced down-regulation of the alpha-2A adrenergic receptor.

It involves a down-regulation of cadherins so that cells can detach from laminin and migrate.

This suggests that down-regulation of survivin by p53 is important for p53-mediated apoptotic pathway to successfully result in apoptosis.

Thus, Sac3 is an insulin-sensitive lipid phosphatase whose down-regulation improves insulin responsiveness.

The reaction of the target cells may then be recognized by the original hormone-producing cells, leading to a down-regulation in hormone production.

However, repeated exposure to hallucinogens leads to rapid tolerance, likely through down-regulation of these receptors in specific target cells.

Thus, it is likely that there are multiple mechanisms that are involved in down-regulation of G protein-coupled receptors.

This is called pituitary down-regulation with a GnRH analogue.

During atrophy, there is a down-regulation of protein synthesis pathways, and an activation protein degradation.

APC effects significant down-regulation of p53 and Bax.

Down-regulation by prostaglandin E1.