No reproduction, despite a great deal of theory to the contrary, can adequately replace an original.

Despite a great deal of study, economists have found no single reason that convincingly explains the decline.

Despite a great deal of study, flashing is still not fully understood, and a solution to the problem would be a major technological advance.

Despite a great deal of confusion and misunderstanding, the federal government generally does not make direct loans under the act.

The authorities say there are no suspects, despite a great deal of digging.

"Despite a great deal of effort, we couldn't match it, I guess because they were trying to break into the market and willing to go further."

Despite a great deal of notice and publicity, no skaters attended.

Despite a great deal of pressure from his family, my father never remarried.

Despite a great deal of discussion, no substantial decisions were made.

The prison opened in 2005, despite a great deal of protest from local residents.