This complex might interact with another C3b and thus form the alternative pathway C5 convertase.

Also Mg2+ ions are necessary for forming a functional C3 convertase.

These together are called the C5 convertase.

The protein may function as a proprotein convertase.

Proprotein convertase 1 is the enzyme largely responsible for the first step in the biosynthesis of insulin.

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family.

The complement component C5 can be also activated by fluid phase C5 convertase.

Catalytic site of C3 convertase is in C2a and Bb subunits.

C3 is cleaved into its a and b subunits, and C3b binds the convertase.

Term C3 convertase may refer to:

It is a membrane protein and regulates also C5 convertase of the classical and alternative pathway.

This convertase, although only produced in small amounts, can cleave multiple C3 proteins into C3a and C3b.

C5 convertase is an enzyme belonging to a family of serine proteases that play key role in the innate immunity.

Another form, the classical pathway C3 convertase contains different proteins of complement system - C4b and C2a.

Chromogranin A is cleaved by an endogenous prohormone convertase to produce several peptide fragments.

In humans, proprotein convertase 2 is encoded by the PCSK2 gene.

The conversion of prohepcidin to hepcidin is mediated by the prohormone convertase furin.

IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase).

Thus, the alternative pathway C3 convertase is formed and is able to cleave C3 now.

Compounds called proprotein convertase inhibitors can block their action, and block the target proteins from becoming active.

Bb will remain associated with C3b to form C3bBb, which is the alternative pathway C3 convertase.

Decay-accelerating factor (DAF) is another negative regulator of C3 convertase.

The prototypical proprotein convertase is furin.

The resultant complex, C3bBb, is called the alternative pathway (AP) C3 convertase.

The modified C5 convertase, C4b2aoxy3b, contains C2a that is derived from C2 oxidized by iodine.