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Many sources include the connecting tubule as part of the collecting duct system.
Connecting tubules of some juxtamedullary nephrons may arch upward, forming an arcade.
With respect to the renal corpuscle, the "connecting tubule" is the most proximal part of the collecting duct system.
Because of this, some sources group the connecting tubule as part of the nephron, rather than grouping it with the collecting duct system.
Some connecting tubules, usually associated with juxtamedullary nephrons, arch upwards before reaching the cortical collecting ducts.
The connecting tubule derives from the metanephric blastema, but the rest of the system derives from the ureteric bud.
Each distal convoluted tubule delivers its filtrate to a system of collecting ducts, the first segment of which is the connecting tubule.
There are several components of the collecting duct system, including the connecting tubules, cortical collecting ducts, and medullary collecting ducts.
Connecting tubules from several adjacent nephrons merge to form cortical collecting tubules, and these may join to form cortical collecting ducts.
As the renal tubules grow, they come into contact and join with connecting tubules of the collecting duct system, forming a continuous passage for flow from the renal tubule to the collecting duct.
However, the embryological origin is more similar to the nephron than it is to the rest of the collecting duct (which derives from the ureteric bud), and other sources therefore classify the connecting tubule with the nephron.
Amiloride works by directly blocking the epithelial sodium channel (ENaC) thereby inhibiting sodium reabsorption in the late distal convoluted tubules, connecting tubules, and collecting ducts in the kidneys (this mechanism is the same for triamterene).
In the kidney, the connecting tubule (CNT, or junctional tubule, or arcuate renal tubule) is a tubular segment of the renal collecting duct system that connects the distal convoluted tubule to the cortical collecting duct.
The first time Harman had seen the ruined structure from a distance, he'd thought the huge towers and heavy horizontal connecting cables were wrapped about with bright green ivy, but he knew now that these green bubbles, hanging vines, and connecting tubules were the actual habitation structures, probably added centuries after the bridge itself was built.