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In contrast, decreased glutamate release is observed under conditions of classical phenylketonuria leading to developmental disruption of glutamate receptor expression.
-Phenylalanine also inhibits neurotransmitter release at glutamatergic synapses in hippocampus and cortex with IC of 980 M, a brain concentration seen in classical phenylketonuria, whereas -phenylalanine has a significantly smaller effect.
Classical Phenylketonuria Hyperphenylalanemia Phenylalanine Hydroxylase Deficiency Phenylalaninemia PKU None Phenylketonuria (PKU) is an inborn error of metabolism that is detectable during the first days of life with appropriate blood testing (e.g., during routine neonatal screening).