Serious (grade 3 or 4) adverse events occur in 10% of patients and include hypertension, fatigue, asthenia, diarrhea, and chemotherapy-induced acral erythema.

Chemotherapy-induced acral erythema (also known as "palmar-plantar erythrodysesthesia" or "hand-foot syndrome") is reddening, swelling, numbness and desquamation on palms and soles that can occur after chemotherapy in patients with cancer.

Abstract Chemotherapy-induced acral erythema (CIAE), a toxic reaction to a number of different chomotherapeutic agents, causes a symmetrical, painful erythema of both the palms and soles which is self-limiting.