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Occasionally, an early fallopian tube cancer may be detected serendipitously during pelvic surgery.
Ovarian cancer, including fallopian tube cancer and primary peritoneal cancer.
Women with a BRCA mutation have more than 100 times the normal rate of Fallopian tube cancer.
There are now several lines of evidence indicating that primary fallopian tube cancer should be considered a part of the BRCA1/2 phenotype.
Primary fallopian tube cancers, primary peritoneal cancers, and occult ovarian cancers have all been reported.
Fallopian tube cancer, which typically arises from the epithelial lining of the Fallopian tube, has historically been considered to be a very rare malignancy.
Germline mutations in BRCA1 are associated with early-onset breast cancer, ovarian cancer, and fallopian tube cancer.
BRCA-related ovarian and Fallopian tube cancer is more treatable than average because it is unusually susceptible to platinum-based chemotherapy like cisplatin.
While tubal cancers may be misdiagnosed as ovarian cancer, it is of little consequence as the treatment of both ovarian and Fallopian tube cancer is similar.
Primary fallopian tube cancer (PFTC), often just tubal cancer, is a malignant neoplasm that originates from the fallopian tube.
Although genetic testing is freely available in Canada to women diagnosed with ovarian cancer or fallopian tube cancer, only 80 of 416 women surveyed (19%) had undergone clinical genetic testing.
Women with BRCA gene mutations usually also have their fallopian tubes removed at the same time (salpingo-oophorectomy), since they also have an increased risk of fallopian tube cancer.
For example, while CA-125 is best known as a marker for ovarian cancer, it may also be elevated in other cancers, including endometrial cancer, fallopian tube cancer, lung cancer, breast cancer and gastrointestinal cancer.
Berkenblit A, Seiden MV, Matulonis UA, et al.: A phase II trial of weekly docetaxel in patients with platinum-resistant epithelial ovarian, primary peritoneal serous cancer, or fallopian tube cancer.
Some surgeons have recommended hysterectomy in addition to RRSO to remove the remnant of fallopian tube tissue embedded in the uterus, but there is no consensus on this issue, and most, if not all, fallopian tubes cancers appear to arise in the more distal segments of the tube.