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He currently suffers from a rare disease called capillary leak syndrome.
There are post-marketing reports of capillary leak syndrome resulting in death.
These symptoms were not required to occur simultaneously to be characterized as capillary leak syndrome.
The onset of symptoms in patients with capillary leak syndrome may be delayed, occurring up to 2 weeks following infusion.
These toxicities include neuropathic pain, capillary leak syndrome, and hypersensitivity reaction.
These include flulike symptoms, as well as capillary leak syndrome, which can cause low blood pressure and swelling.
Known as capillary leak syndrome, this causes both systemic hypotension and tissue oedema.
Several causes have been speculated, including a capillary leak syndrome from cytokine release from the differentiating myeloid cells.
Certain plant-derived anticancer chemotherapeutic agents, such as docetaxel, cause anasarca through a poorly understood capillary leak syndrome.
Not the patients who died after contracting raging bacterial infections, capillary leak syndrome, bleeding inside the brain, and irreversible kidney failure-all caused by these drugs.
While some reports were positive, others have reported capillary leak syndrome suspected to be the result of overly rapid lowering of VEGF levels.
Capillary leak syndrome also leads to abnormally high hematocrit counts, because of the episodic leakage of plasma out of the circulatory system.
The etiology of retinoic acid syndrome has been attributed to capillary leak syndrome from cytokine release from the differentiating promyelocytes.
Blood vessels become permeable, which increases the danger of capillary leak syndrome, in which fluid leaks out of the veins until the body becomes grotesquely swollen.
The precise mechanisms of the capillary leak syndrome in TRALI have not been fully determined, but two main hypotheses have been proposed.
But in 2005, at age 56, Porzecanski was told he had an extraordinarily rare disease called systemic capillary leak syndrome (SCLS), or Clarkson's disease.
As defined, capillary leak syndrome was reported in 32.5% (76/234) of ONTAK-treated patients in clinical studies; one-third required hospitalization or medical intervention to prevent hospitalization.
More serious and dangerous side effects sometimes are seen, such as capillary leak syndrome, breathing problems, serious infections, seizures, allergic reactions, heart problems or a variety of other possible complications.
Its cause is unknown, but it is unrelated to capillary leak syndrome (which may cause similar swelling episodes) and eosinophilia-myalgia syndrome (which features eosinophilia but alternative symptoms).
Abnormal distribution may, however, occur in certain cases such as during the first 24 hours after severe burns or septic shock - capillary leak syndrome - which may lead to multi-organ failure.
Edema, capillary leak syndrome, pleural and or/pericardial effusion, supraventricular tachycardia, sequestration of granulocytes in the pulmonary circulation and dyspnea have been reported in patients after Leukine administration.
Immediately stop and permanently discontinue ONTAK for serious infusion reactions [see Warnings and Precautions (5.1)]. -- Capillary leak syndrome resulting in death.
Proleukin administration has been associated with capillary leak syndrome (CLS), which is characterized by a loss of vascular tone and extravasation of plasma proteins and fluid into the extravascular space.
Since late 2005, Porzecanski has struggled with an exceedingly rare illness, Systemic Capillary Leak Syndrome (SCLS), which left him partially disabled and brought him near death several times.
Damage to the endothelial layer of blood vessels caused by these inflammatory mediators can lead to capillary leak syndrome, dilation of blood vessels and a decrease in cardiac function and can lead to septic shock.