Once the biochemical diagnosis of a catecholamine-secreting tumor is confirmed, localization studies should be performed.

Several reviews provide a succinct summary of the biochemical diagnosis, localization, and management of pheochromocytoma.

The isolation of enzymes from infected tissue can also provide the basis of a biochemical diagnosis of an infectious disease.

Lenders JW, Pacak K, Walther MM, et al.: Biochemical diagnosis of pheochromocytoma: which test is best?

It is thought that this disorder might be under-diagnosed for a few different reasons - the diagnosis is often made late in the disease's progression, symptoms are often mild, or the biochemical diagnosis does not yield conclusive results.

Pacak K, Ilias I, Adams KT, et al.: Biochemical diagnosis, localization and management of pheochromocytoma: focus on multiple endocrine neoplasia type 2 in relation to other hereditary syndromes and sporadic forms of the tumour.

The best single biochemical marker for polycystic ovary syndrome is a raised testosterone level, but "combination of SHBG and testosterone to derive a free testosterone value did not further aid the biochemical diagnosis of PCOS".