Second, a protease inhibitor was used to counter any autoactivation which may have occurred during isolation.

This leads to the autoactivation of caspase-1, an enzyme that processes proinflammatory cytokines (IL-1b and IL-18).

It appears that plasmepsin II and IV are capable of autoactivation as well as activation each other's inactive form.

Pro-Caspase-8 and pro-caspase-9 bind to specific adaptor molecules via DED domains and this leads to autoactivation of caspases.

C1 occurs in serum as a proenzyme that tends to undergo autoactivation but is strictly controlled by C1-inhibitor (C1-In or C1 esterase).

Thus, on binding to immune complexes through C1q, the subunits of C1 become firmly associated and autoactivation commences even in the presence of the Cl-In.

A synchronized inhibition of factor XII autoactivation by Apo-H and AHAA has been suggested.

KLK5 is able to undergo autoactivation, as well as activating KLK7 and KLK14, suggesting a KLK skin cascade is responsible for coordinating desquamation.

ARQ 197 strongly inhibits c-Met autoactivation by selectively targeting the inactive form of the kinase between the N- and C- lobes and occupies the ATP binding site.

The mechanism by which these genetic mutations cause pancreatitis is incompletely understood but is likely to be the result of increased autoactivation or reduced deactivation of trypsinogen (or a combination of the two), although a novel mechanism has recently been identified in a p.R116C kindred.

AAHA also inhibited the autoactivation of factor XII while at high AAHA concentrations, factor XIIa activation increases at levels comparable to Apo-H that cause inhibition of factor XIIa activation.