IgG antibodies are smaller and require assistance to bridge well enough to form a visual agglutination reaction.

The term can also be used for inhibiting antibody, prozone phenomenon and, agglutination reaction.

FFP should be blood type-matched to ensure compatibility, as agglutination reactions are possible, though rare.

Austrian physician Karl Landsteiner found another important practical application of the agglutination reaction in 1900.

Transmittance of light may be used to measure e.g. clearing of opacity of a liquid created by suspended particles due to decrease in number of clumps during a platelet agglutination reaction.

The ability to control antigen levels on the outside of a kodecyte has allowed for manufacture of quality control sensitivity systems and serologic teaching kits incorporating the entire range of serologic agglutination reactions.