Sertoli cell only syndrome is likely multifactorial, and characterized by severely reduced or absent spermatogenesis despite the presence of both Sertoli and Leydig cells.

The Sertoli cell-only syndrome patients normally have normal secondary male features and have normal- or small-sized testes.

Mutations in this gene have been associated with Sertoli cell-only syndrome (SCO) and male infertility.

Sertoli cell-only syndrome (a.k.a. Del Castillo syndrome and germ cell aplasia ) is a disorder characterized by male sterility without sexual abnormality.

Sertoli cell-only syndrome (a.k.a. Del Castillo syndrome and germ cell aplasia ) is a disorder characterized by male sterility without sexual abnormality.

Dr. Del Castillo, Dr. Trabucco and Dr. De la Balze described and studied what today is known as Del Castillo syndrome.

Sertoli cell-only syndrome (a.k.a. Del Castillo syndrome and germ cell aplasia ) is a disorder characterized by male sterility without sexual abnormality.

Recognized patterns include: normal spermatogenesis, hypoplasia or hyposperm ato genesis, complete or early maturation arrest, Sertoli cell-only or germ cell aplasia, incomplete or late maturation arrest, and sclerosis.