Rozrolimupab (Sym001) is a polyclonal antibody used in the treatment of autoimmune thrombocytopenic purpura, prevention of isoimmunization in Rh-negative pregnant women.
An Rh-negative woman can only become pregnant with an Rh-positive fetus if the father is Rh-positive.
Clarke helped to develop the technique of giving Rh-negative women inter-muscular injections of anti-RhD antibodies during pregnancy to prevent Rh disease in their newborn babies.
Erythroblastosis fetalis: A form of anemia that develops in the Rh-positive infants of Rh-negative women.
This preservative is also used in some immunoglobulins given to pregnant Rh-negative women and some over-the-counter eardrops and nasal sprays.
Rh immune globulin is given to all Rh-negative women who may be carrying an Rh-positive fetus.
Anti-D is normally administered to Rh-negative women during pregnancy and after the birth of an Rh-positive infant, to prevent sensitization to the Rh factor in the newborn.
If you are an Rh-negative woman and you become pregnant, you must tell your doctor if you have ever been exposed to Rh-positive blood in your lifetime.
Therefore, unsensitized Rh-negative women are given Rh immune globulin after amniocentesis to prevent sensitization.
(To prevent sensitization in future pregnancies, Rh immune globulin is also given when an Rh-negative woman has a miscarriage, abortion, or ectopic pregnancy.)
