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These symptoms were found in rare cases of Larsen syndrome.
Treatment for Larsen syndrome varies according to the symptoms of the individual.
These individuals often have more severe symptoms than those with classic Larsen syndrome.
None Larsen syndrome is a rare genetic disorder that has been associated with a wide variety of different symptoms.
Both autosomal dominant and recessive forms of Larsen syndrome have been reported.
These symptoms are all associated with Larsen syndrome, and therefore they can be used to confirm that a fetus has the disorder.
Larsen syndrome can also cause a variety of cardiovascular anomalies and orthopedic abnormalities.
Orthopedic surgery can be performed to correct the serious joint defects that are associated with Larsen syndrome.
It is not clear whether these individuals have an autosomal recessive form of Larsen syndrome or a similar, yet distinct, disorder.
The defect in the epiphyseal growth plates can cause short stature and other symptoms associated with Larsen syndrome.
Larsen syndrome has recently been described as a mesenchyme disorder that affects the connective tissue of an individual.
Ultrasound remains as one of the only effective ways of prenatally diagnosing Larsen syndrome.
The autosomal dominant form is significantly more common than the autosomal recessive form of Larsen syndrome.
The classic form of Larsen syndrome is caused by mutations of the FLNB gene.
Genetic analysis has found that a gene linked to Larsen Syndrome, LAR1, is strongly linked to chromsome 3p markers.
The gene that influences the emergence of Larsen syndrome is found in chromosome region, 3p21.1-14.1, a region containing Human type VII collagen gene.
Larsen syndrome (LS), is a congenital disorder discovered in 1950 by Larsen and associates when they observed dislocation of the large joints and face anomalies in six of their patients.
Reports have found that in Western societies, Larsen syndrome can be found in 1 in every 100,000 births, however, this is most likely an underestimate because the disorder is frequently unrecognized or diagnosed as another disorder.
Patients suffering from Larsen syndrome normally present with a variety of symptoms including: congenital anterior dislocation of the knees, dislocation of the hips and elbows, flattened facial appearance, prominent foreheads, and depressed nasal bridges.
It is reasonable to believe that the joint abnormalities and cardiac anomalies associated with Larsen syndrome are related to the fact that the Human type VII collagen gene is found within the same chromosome region as the LAR1 gene.
While Larsen syndrome can be lethal if untreated, the prognosis is relatively good if individuals are treated with orthopedic surgery, physical therapy, and other procedures used to treat the variety of symptoms linked with Larsen syndrome.
Genetic analysis of patients with Larsen syndrome has found that Larsen syndrome is caused by missense mutations in the gene that codes for filamin B. These mutations cause an accelerated rate of apoptosis in the epiphyseal growth plates of individuals with the mutation.