The reagent is used in an acidic modification of the Hofmann rearrangement.

The Hofmann rearrangement and Hofmann elimination reaction bear his namesake.

Reacting this with an alkaline solution of a halogen (Hofmann rearrangement) gives baclofen.

Hofmann rearrangement in the presence of a bromine and a base converts the iminoester to the corresponding primary amine.

The Hofmann rearrangement is the organic reaction of a primary amide to a primary amine with one fewer carbon atom.

Isocyanates are intermediates in the Hofmann rearrangement, in which a primary amide is treated with sodium hypobromite to form an isocyanate intermediate.

NBS, in the presence of a strong base, such as DBU, reacts with primary amides to produce a carbamate via the Hofmann rearrangement.

In the next step iodobenzene diacetate is added, converting the amide in a Hofmann rearrangement to the allyl carbamate 12 after capturing the intermediate isocyanate with allyl alcohol 11.

SNF also manufactures synthetic dry strength resins which are acrylamide based, glyoxalated (FLOSTRENGTH) or issued from Hofmann rearrangement.