It inhibits leukotriene synthesis to provide therapy in rheumatologic illness.

Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis.

Acetyl-boswellic acids also exhibit anti-inflammatory behaviour by inhibiting leukotriene synthesis.

If NSAIDs directly enhance leukotriene synthesis this may also contribute to mucosal injury.

Zileuton (Zyflo), an asthma drug taken four times per day, blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway.

Glutathione (GSH) participates in leukotriene synthesis and is a cofactor for the enzyme glutathione peroxidase.

Cosupplementation with GLA and EPA lowers serum AA levels by blocking Δ-5-desaturase activity, while also lowering leukotriene synthesis in neutrophils.

A trigger for leukotriene synthesis may be the formation by ionising radiation of lipid peroxides, which may in turn promote synthesis of leukotrienes by LTA 4 hydrolase.

Studies have shown that one of Sulfad's active constituents has a number of effects including inhibition of neutrophil migration, marked inhibition of leukotriene synthesis and formation of prostaglandins.

Paraxanthine is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene synthesis, and reduces inflammation and innate immunity.

If, as we believe, the main source of mucosal reactive oxygen species in inflammation is the neutrophil, then leukotriene synthesis inhibitors could prevent aggregation of neutrophils in the mucosa, thus decreasing reactive oxygen species and tissue injury.