Both the kappa and the lambda chains can increase proportionately, maintaining a normal ratio.

Ig lambda chain C regions is a protein that in humans is encoded by the IGLC2 gene.

Translation of the spliced mRNA for either the kappa or lambda chains results in formation of the Ig κ or Ig λ light chain protein.

Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the kappa type, in contrast to the usual concordance between a translocation involving chromosome 22 and lambda chain synthesis.