Diffuse brain injuries tend to slow thought; very high intelligence provides a margin to spare.

Brain injuries may be Focal and diffuse brain injury, occurring over a wide area, or focal, located in a small, specific area.

"The major mechanism of primary diffuse brain injury after blunt head trauma is the mechanical shearing and tearing of nerve fibers and blood vessels.

A type of diffuse brain injury, multiple petechial hemorrhages are not always visible using current imaging techniques like CT and MRI scans.

Focal and diffuse brain injury are ways to classify brain injury: focal injury occurs in a specific location, while diffuse injury occurs over a more widespread area.

Acute subdural bleeds have a high mortality rate, higher even than epidural hematomas and diffuse brain injuries, because the force (acceleration/deceleration) required to cause them causes other severe injuries as well.

In the intensive care unit, raised intracranial pressure (intracranial hypertension) is seen frequently after a severe diffuse brain injury (one that occurs over a widespread area) and leads to cerebral ischemia by compromising cerebral perfusion.

Primary and secondary brain injury are ways to classify the injury processes that occur in brain injury, while focal and diffuse brain injury are ways to classify the extent or location of injury in the brain.

Likewise, animal models of diffuse brain injury have illustrated a fencing response upon injury at moderate but not mild levels of severity as well as a correlation between fencing, blood brain barrier disruption, and nuclear shrinkage within the LVN, all of which indicates diagnostic utility of the response.