Multidimensional screening was introduced in 2002 and has provided insights into tumorigenesis, cell polarity, and chemical space, among others.
Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.
The relative levels of the alternate forms may be regulated and involved in the normal control of planar cell polarity.
Refinement of these studies showed that gap junctions appeared to be key to development of cell polarity and the left/right symmetry/asymmetry in animals.
Flamingo was originally identified as a Drosophila protein involved in planar cell polarity.
The Bretscher lab studies how microfilaments contribute to cell organization and cell polarity.
He is known for his contributions to the generation of planar cell polarity in the Drosophila melanogaster epithelium.
Many of the molecules responsible for regulating cell polarity are conserved across cell types and throughout metazoan species.
Dishevelled plays important roles in both the embryo and the adult, ranging from cellular differentiation and cell polarity to social behavior.
His research focuses on microfilaments and cell polarity.