The clearance of Sym004 is dependent on antibody mediated receptor internalization.

Inside the cell the C-terminus domain contains a signal sequence that is needed for receptor internalization.

Dab2 links CIN85 with clathrin-mediated receptor internalization.

As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration.

Later projects include investigation of LDL cholesterol receptor internalization, cellular sorting machinery, and the cellular basis for immunity.

Repeated administration of receptor agonists may result in receptor internalization and/ or a reduction in receptor protein signalling.

Endocytosis is mediated through NPxY sequences known to signal for receptor internalization through clathrin-coated pits.

Due to the efficiency of Sym004 induction of receptor internalization, repeat dose studies showed little accumulation of Sym004 and the clearance rate was higher than Cetuximab.

Unlike most μ-opioid agonists, herkinorin does not promote the recruitment of β-arrestin-2 to the intracellular domain of the μ-opioid receptor, or induce receptor internalization.

At high plasma concentrations, the number of surface receptors for insulin is gradually reduced by the accelerated rate of receptor internalization and degradation brought about by increased hormonal binding.

PKC phosphorylates AMPA receptors, causing receptor internalization as is seen in hippocampal LTD.

Inactivation of the 5-HT receptor, however, does not arise from the classically described mechanisms of receptor desensitization via receptor phosphorylation, beta-arrestin recruitment, and receptor internalization.

These results bring an important confirmation that data obtained in an in vitro system for G protein-coupled receptor internalization ( 3) are relevant to the CNS in vivo .

Apart from affecting the affinity and specificity for Trk receptor, P75 neurotrophins receptor (P75NTR) can also reduce ligand-induced receptor ubiquitination, delays receptor internalization, and degradation.

Serotonin, in cooperation with a group I metabotropic glutamate receptor (mGluR) agonist, facilitates LTD induction through augmentation of AMPA receptor internalization.

Hitchcock I, Chen M, Fox NE, Kaushansky K. YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation.

Second, arrestins link the receptor to elements of the internalization machinery, clathrin and clathrin adaptor AP2, which promotes receptor internalization via coated pits and subsequent transport to internal compartments, called endosomes.

One of the important features of GHSR1a displays constitutive activity possessing basal activity in the absence of an agonist, resulting in a high degree of receptor internalization as well as of signaling activity.