This radiolabeling enables the study of the serotonin-2A receptor distribution in the human brain.

It is the compression of receptor distribution that results in greater stimulation and thus a larger perceived image of an object.

Non-uniform stretching or compression of the receptor distribution could explain the field dependency of the macrospia.

Macropsia may be a result of optical magnification differences between the eyes, retinal receptor distribution, or the cortical processing of the sampled image.

Alterations in receptor distribution can be the result of epiretinal membrane, neuroretina detachment and/or re-attachment, or retinoschisis.

This attenuation did not appear to be accompanied by a reduction in cell surface expression levels of receptor nor by an obvious change in receptor distribution in the cells.

Similar experiments using a GFP-tagged group I mGluR, GFP-mGluR1a, indicated no detectable changes in receptor distribution when coexpressed with Siah1a (figure 3C).

At the level of scanning electron microscopy, membrane regions rich in AChRs (whether spontaneous or induced by agrin or laminin) show receptor distributions which appear decidedly non-random (Figure 2).

If the compression forces were closer to the fovea the resulting compression would cause a greater amount of macropsia at lower field angles with little effect at higher field angles where the receptor distribution is not as compressed.

Macropsia arises from a compressed receptor distribution leading to a larger perceived image size and conversely, micropsiaresults from stretching of the retina leading to a more sparse receptor distribution that gives a smaller perceived image size.