These initiatives are all based on scientific criteria and quantitative thresholds.

It does not however set out quantitative thresholds or scales for damage, death or injury respectively.

Secondly, the setting of quantitative thresholds raises the problem of their revision and updating.

Ignoring the qualitative calls in an analysis of the replicate 129SvEv cerebellum data and using only quantitative thresholds (a fold change greater than 1.8 and an average difference change greater than 50) yielded a long list of 715 genes scored as differentially expressed.

Firstly, the removal from the scope of the Directive, and consequently from its benefits, of the majority of companies which are not strictly financial; not only small and medium ones, but also large companies which do not reach those very high quantitative thresholds which I have mentioned.