Even in this individual therapy, the central focus was inter-patient relationships.

Adaptive control techniques will be used to compensate for intra-patient and inter-patient variability.

"Intoxication type reactions" appear to be dose-related, increasing in frequency with higher dosages, and subject to great inter-patient variability.

This showed that sample mixing does indeed average out tissue heterogeneity (intra-patient variability), as well as inter-patient variability.

It is not possible to define a standard procedure for complex interventions due to the large inter-patient variations with regard to the complexity of specific interventional procedures.

The above findings suggested that both intra-patient variability (tissue heterogeneity) and inter-patient variability (polymorphic noise) had major effects on the expression profiles.

The disease commonly leads to dependence on a wheelchair within twenty to thirty years of symptom onset, but there is high inter-patient variability, with some patients maintaining mobility.

Poor patient compliance with burdensome triple-drug therapy and problems related to drug pharmacokinetics due to inter-patient variability are often cited as the cause of that virologic failure.

Important inter-patient variability was observed for Cmin and no correlation was found between this PK parameter and either the dose or the patient's age.

Predictors of inter-patient toxicity in a phase I trial of NX211 given in a daily x 3 intravenous infusion schedule every 3 weeks.

Esomeprazole magnesium (brand name Nexium) received its first approval in 2000 and provided more pronounced inhibition of acid secretion and less inter-patient variation compared to omeprazole.

To study inter-patient variability, we defined the gene expression changes surviving four pairwise comparisons with mixed control samples, as we have previously described [ 23 ] .

An alternative method is to experimentally normalize these variables through mixing of samples from patient groups; such mixing would be expected to average out both intra- and inter-patient variation.

Although dose-response curves are characterized by a wide inter-patient variability, 90% of the pulmonary vascular effect is obtained for NO concentrations 4.5 ppm in patients with or without septic shock.

In recent clinical trials GO has been shown to induce remission and improve survival in subset of patients with AML, however there is wide inter-patient variation in response.

As a result, intra- and inter-patient variability in parameters, such as area under the curve to the time of collection (AUCt) and clearance (CL), were observed among the three pharmacokinetic assessments.

We have shown that mixing of patient samples effectively normalizes much of the intra- and inter-patient noise, while still identifying the majority of the most significant gene expression changes that would have been detected by larger numbers of individual patient profiles.

Epidemiologically, HLA genotype partially accounts for inter-patient variation in disease severity or progression rates for such long-term viral infections as HIV, human T-cell lymphotropic virus, type 1 (HTLV-1), and hepatitis B and C [ 5 6 7 8 9 ] .

Apparent outbreaks attributed to S. maltophilia are frequently caused by multiple strains, implying acquisition from environmental sources as opposed to inter-patient spread.

Many of these drugs have wide interpatient dose variability.

Astra started a new research program in 1987 to identify a new analogue to omeprazole with less interpatient variability.

In leukemia cells from patients, we and others have found a 40-fold interpatient variation in expression of the es transporter.

Interpatient analysis revealed 9 karyotypes and 17 RAPD composites.

Interpatient Variability in the Risk-Benefit Balance Initiator :

This was comparable with the interpatient variation reported by others using laser Doppler, venous outflow collection, and isotope clearance techniques in the gastrointestinal tract.

The CPT report noted consistent allegations of mistreatment of patients by staff as well as of interpatient violence, in particular at Demir Hisar Psychiatric Hospital.