Histologic evidence of granulomatous hepatitis (hepatic biopsy)

Quinidine can cause thrombocytopenia, granulomatous hepatitis, myasthenia gravis, and torsades de pointes, so is not used much today.

Granulomatous hepatitis with marked elevations in serum alkaline phosphatase and granulomas on liver biopsy have been reported in patients with SSZ hepatotoxicity [ 22 23 24 ] .

The disease's sequelae are highly variable and may include granulomatous hepatitis, arthritis, spondylitis, anaemia, leukopenia, thrombocytopenia, meningitis, uveitis, optic neuritis, endocarditis, and various neurological disorders collectively known as neurobrucellosis.

Although liver tissue was not obtained in our patient, the predominance of serum alkaline phosphatase and bilirubin level elevations and the presence of granulomas in other tissues suggest that she probably had granulomatous hepatitis.

Proctor DD, Chopra S, Rubenstein SC, Jokela JA, Uhl L. Mycobacteremia and granulomatous hepatitis following initial intravesical bacillus Calmette-Guerin instillation for bladder carcinoma.