However, metabolic pathways are not just regulated through inhibition since enzyme activation is equally important.

Also, mechanisms other than enzyme activation, such as Ca-dependent activation, can theoretically be used.

Metabolic derangements that lead to impaired cell function and proteolytic enzyme activation.

PeaB - quinohemoprotein amine dehydrogenase maturation protein (enzyme activation)

AtsB - anaerobic sulfatase activase (enzyme activation)

NrdG - anaerobic ribonucleoside-triphosphate reductase activase (enzyme activation)

PflA - pyruvate formate-lyase activating enzyme (enzyme activation)

Over the past decade, digestive enzyme activation by lysosomal hydrolases (particularly cathepsin B) has been implicated as the initial event in three forms of experimental pancreatitis.

Grapefruit juice and/or cimetidine or hydroxyzine may also inhibit liver enzyme activation, thus increasing the strength and duration of the opiate effects.

This availability, in combination with a useful and very unusual chemistry, may have led to its usefulness in evolution as an ion for signaling, enzyme activation and catalysis.

The hydrophobic interactions with catalytic loop F583 and DFG motif F595 stabilize the inactive conformation of these structures, decreasing the likelihood of enzyme activation.

It is used in metabolic and biochemical reactions such as DNA synthesis and repair, protein synthesis, prostaglandin synthesis, amino acid transport, and enzyme activation.

If conformation is altered as result of post-translational modification, enzyme activation, drug binding or other functional events, there will likely be a change to H/D exchange that can be detected.

The proteins are typically lysosomal or secreted, and proteolytic cleavage of the propeptide is required for enzyme activation, although bleomycin hydrolase is cytosolic in fungi and mammals.

They exhibit their effect by inducing Phase I and Phase II enzymes, inhibiting the enzyme activation, modifying the steroid hormone metabolism and protecting against oxidative damages.

In keeping with the biological definition of thermogenesis, all three of these enzyme activations drive energy-producing substrates in a direction of less efficient ATP production relative to heat production.

Pantothenic acid in the form of CoA is also required for acylation and acetylation, which, for example, are involved in signal transduction and enzyme activation and deactivation, respectively.

Examples of radical SAM enzymes include various enzymes of cofactor biosynthesis, enzyme activation, peptide modification, metalloprotein cluster formation, tRNA modification, lipid metabolism, etc.

It should be noted that phosphate addition and removal do not necessarily correspond to enzyme activation or inhibition, and that several enzymes have separate phosphorylation sites for activating or inhibiting functional regulation.

There are 2 regulation systems at work when the cycle needs to be turned on or off: thioredoxin/ferredoxin activation system, which activates some of the cycle enzymes, and the Rubisco enzyme activation, active in the Calvin cycle, which involves its own activase.

Long chain fatty acyl-CoA synthetase, LC-FACS, plays a role in the physiological regulation of various cellular functions via the production of long chain fatty acyl-CoA esters, which reportedly have affected protein transport, enzyme activation, protein acylation, cell signaling, and transcriptional regulation.

This change in function can mimic the effect of the endogenous substance in which case the effect is referred to as receptor agonism (or channel or enzyme activation) or be the opposite of the endogenous substance which in the case of receptors is referred to as inverse agonism.