This is known as endotoxic shock, and can be rapidly fatal.

So, a wide variety of different organisms can produce endotoxic shock.

This may lead to endotoxic shock, which may be fatal.

The first major study of ibuprofen in endotoxic shock was performed by Jacobs et al. [ 5 ] .

The numbers of white blood cells are reduced in experimental animals induced with endotoxic shock [ 24 ] .

Vibrio vulnificus infections also disproportionately affect males; 85% of those who develop endotoxic shock from the bacteria are male.

TxA 2 is a product of arachidonic acid and a potent platelet aggregator, whose levels increase during endotoxic shock.

If the bowel becomes sufficiently ischemic, bacteria may enter the blood stream, resulting in the increased complication of endotoxic shock.

In endotoxic shock, bacterial endotoxin enters the systemic circulation and triggers the release of pro-inflammatory mediators.

If a high amount of LPS is present then septic shock (or endotoxic shock) may result which, in severe cases, can lead to death.

This study indicated that ibuprofen can limit the degree of hypotension and acidosis, and decrease the cardiac index in endotoxic shock.

Survival rates Among the three endotoxic shock groups, the longest mean survival time was observed in Group IV (383.0 39.0 minutes).

Clinical signs are similar to those of other diarrheal diseases, including toxemia caused by Clostridium, Potomac horse fever, experimental endotoxic shock, and anaphylaxis.

In this study, we investigated the effects of ibuprofen on physiological parameters and survival in pre- and post-treated rabbits with experimentally induced endotoxic shock.

In addition, Young and Passmore [ 33 ] reported that ibuprofen-treated canines with induced endotoxic shock had longer survival times than those treated with propylgallate.

Hypovolemic and endotoxic shock are manifest by increased capillary refill time, congested or cyanotic (purplish) mucous membranes, and cold extremities.

The canine parvovirus, which causes death by dehydration, electrolyte imbalance, and endotoxic shock or sepsis, is largely surviveable in wolves, but can be lethal to pups.

Herbertson et al. [ 9 ] showed that ibuprofen administration in endotoxic shock in pigs could prevent the early hemodynamic changes following entotoxemia, but not the later changes.

"I think the image that I retain was that of a 31-year-old Mexican-American woman who died of endotoxic shock with her husband and four or five children around," he says.

Beck and Abel [ 20 ] reported that administration of ibuprofen before endotoxin blocked the sudden drop in mean arterial pressure in experimentally-induced endotoxic shock in dogs.

Ginkgolides, especially ginkgolide B, are potent antagonists against platelet-activating factor, and thus may be useful in protection and prevention of thrombus, endotoxic shock, and from myocardial ischeamia.

NSAIDs were first used by Northover and Subramanian [ 11 ] in an endotoxic shock model in dogs, in order to improve hemodynamic disorders.

The endotoxic shock mouse model reported by Rosello et al. [ 30 ] showed that the levels of PGE 2 were significantly lower in the ibuprofen-treated group than in controls.

The onset of DIC can be fulminant, as in endotoxic shock or amniotic fluid embolism, or it may be insidious and chronic, as in cases of carcinomatosis.

Hamilton AJ, Carr DB, LaRovere JM, Black PM: Endotoxic shock elicits greater endorphin release than hemorrhage.